Metal nanoparticles coated with SAMs of carboxylic acid thiols have been used widely for the immobilization of biomolecules. In these applications, the pH of the NP suspension needs to be adjusted slightly above the pKa of the COOH groups in the SAM (ca. 6-8; see J. Am. Chem. Soc. 2006, 128, 15046; 2007, 129, 6664). The negatively charged NPs thus prepared interact attractively with the positively-charged amino acid side chains of proteins or with heme-containing redox enzymes (Biochemistry, 1993, 32, 13771). Toxicity studies (summarized in Small 2008, 1, 26) show that these NPs have very low toxicity against multiple cell types. Recently, Au/COOH nanoparticles have also been used as building blocks for nanoparticle supracrystals (Science 2006, 312, 420; Nano Lett. 2007, 7, 1018) and as components of “patchy” nanoparticle coatings formed on different types of materials by electrostatic interactions (J. Am. Chem. Soc. 2007, 129, 15623.

我们为功能化自组装单分子膜开发和销售化学品。我们的选择是真正独特的，我们设计的化合物可以用于修饰金属(金、银、铂、铜等)、玻璃、硅、氧化物或复合表面。我们提供的硫醇、二硫醇、硅烷、儿茶酚和偶联剂都经过严格的纯度和效率测试。

ProChimia Surfaces is a privately held company established in 2001 and located in Gdansk area, Poland. Capitalizing on interdisciplinary expertise in the fields of chemistry, nanotechnology, and biotechnology, ProChimia delivers state-of-the-art solutions for chemical and biochemical modification of various types of surfaces and materials.