Description

This unique line of thiols offers a range of truly exciting surface immobilization schemes. The EG linker makes these compounds suitable for inclusion in mixed SAMs resisting nonspecific absorption (with simple EGn thiols as the background; cf. cat # TH000 - TH005), and the azide group provides a biospecific handle for Sharpless "click" chemistry. (Angew. Chem. Int. Ed. 41, 2596, 2002) towards acetylene-bearing reagents.



It has been recently been shown that the click chemistry can be used to immobilize various (bio)molecules chemoselectively and in excellent yields (J. Am. Chem. Soc. 127, 8600, 2005), and that it can be coupled with electrochemistry to allow for site-selective immobilization (J. Am. Chem. Soc. 128, 1794-1795, 2006 and also Science, Editor's Choice, 10 February, 2006). In the latter case, application of voltage bias to a gold microelectrode supporting azide-terminated SAM changed the redox state of an auxiliary copper catalyst, and thus activated the SAM for the "click" chemistry. By activating different microelectrodes at different times, it was possible to immobilize various molecules onto them. The capability of such sequential immobilization should prove extremely useful in the development of electrochemical microsensor arrays.



Note: Please see our related product Cat. FT 010-m11 (under Functionalized Thiols) and also silane analogs for functionalization of glass, Si and PDMS (under Silanes).

我们为功能化自组装单分子膜开发和销售化学品。我们的选择是真正独特的，我们设计的化合物可以用于修饰金属(金、银、铂、铜等)、玻璃、硅、氧化物或复合表面。我们提供的硫醇、二硫醇、硅烷、儿茶酚和偶联剂都经过严格的纯度和效率测试。

ProChimia Surfaces is a privately held company established in 2001 and located in Gdansk area, Poland. Capitalizing on interdisciplinary expertise in the fields of chemistry, nanotechnology, and biotechnology, ProChimia delivers state-of-the-art solutions for chemical and biochemical modification of various types of surfaces and materials.