Description

Thisuniquelineofthiolsoffersarangeoftrulyexcitingsurfaceimmobilizationschemes.TheEGlinkermakesthesecompoundssuitableforinclusioninmixedSAMsresistingnonspecificabsorption(withsimpleEGnthiolsasthebackground;cf.cat#TH000-TH005),andtheazidegroupprovidesabiospecifichandleforSharpless"click"chemistry.(Angew.Chem.Int.Ed.41,2596,2002)towardsacetylene-bearingreagents.



IthasbeenrecentlybeenshownthattheClickchemistrycanbeusedtoimmobilizevarious(bio)moleculeschemoselectivelyandinexcellentyields(J.Am.Chem.Soc.127,8600,2005),andthatitcanbecoupledwithelectRochemistrytoallowforsite-selectiveimmobilization(J.Am.Chem.Soc.128,1794-1795,2006andalsoScience,EditorsChoice,10February,2006).Inthelattercase,applicationofvoltagebiastoagoldmicroelectrodesupportingazide-terminatedSAMchangedtheredoxstateofanauxiliarycoppercatalyst,andthusactivatedtheSAMforthe"click"chemistry.Byactivatingdifferentmicroelectrodesatdifferenttimes,itwaspossIBLetoimmobilizevariousmoleculesontothem.ThecapABIlityofsuchsequentialimmobilizationshouldproveextremelyusefulinthedevelopmentofelectrochemicalmicrosensorarrays.



Note:PleaseseeourrelatedproductCat.FT010-m11(underFunctionalizedThiols)andalsosilaneanalogsforfunctionalizationofglass,SiandPDMS(underSilanes).